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Normal aptt

Activated Partial Thromboplastin Time (APTT) Test & APTT

  1. A typical aPTT value is 30 to 40 seconds. If you get the test because you're taking heparin, you'd want your PTT results to be more like 120 to 140 seconds, and your aPTT to be 60 to 80 seconds
  2. K brist och leversjukdom
  3. APTT är förlängd, men PK(INR) är normalt. Koagulationsutredning visar antikroppar vanligtvis riktade mot FVIII (antikoagulans) och avsaknad av FVIII i patientens plasma. Förvärvad hemofili B eller antikroppar mot annan koagulationsfaktor är extremt sällsynt
  4. al approximation of normal human body temperature).The test is termed partial due to the absence of tissue factor from the reaction mixture. [citation needed]Blood is drawn into a test tube containing oxalate or citrate, molecules which act as.
  5. what is the normal range of aPTT? A typical aPTT value is 30 to 40 seconds. If you get the test because you're taking heparin, you'd want your PTT results to be more like 120 to 140 seconds, and your aPTT to be 60 to 80 seconds. If your number is higher than normal, it could mean several things, from a bleeding disorder to liver disease
  6. They are sometimes called normal values. By comparing your test results with reference values, The partial thromboplastin time (PTT; also known as activated partial thromboplastin time (aPTT)) is a screening test that helps evaluate a person's ability to appropriately form blood clots
  7. The normal APTT supports that intrinsic and common factor pathway factors are not deficient. In general, factors need to be <30% of normal to result in prolonged clotting times. Artifact of collection: The PT may be prolonged with difficult venipuncture or if insufficient blood is collected into citrate

Det normala värdet för PK-INR ska ligga runt 1,0. Om det är lägre finns det risk för trombos hos patienten, om det istället är högre finns det risk för blödning. När en patient behandlas mot risken att drabbas av trombos, så som vid sjukdomen trombofili exmeplevis, då är det bra om patientens värde ligger mellan 2,0 och 3,0. APTT Observera att normal APT-tid inte med säkerhet utesluter en mild hemofili. APTT Tromboplastintid APT-tid blödning DIC hemofili hemostas heparinbehandling heparinterapi intrinsic-system kardiolipinantikropp koagulation lupus-antikoagulans tromboplastintid-partiell-aktiverad

A normal aPTT with an abnormal PT means that the defect lies within the extrinsic pathway and suggests a possible factor VII deficiency. [1, 2, 6, 8] Normal hemostasis. Normal hemostasis is achieved when there is a balance between factors that encourages clotting and factors that encourages clot dissolution Information om koagulering via P-APT-tid. Välkommen att utföra hälsotest via blodprov hos oss på Medisera Health. Beställ på medisera.se, få digitalt läkarkommenterat provsvar i Min Journal via Bank-ID, snabbt, enkelt & patientsäkert. Provtagning med hög klinisk standard i samarbete med bl.a. Karolinska Universitetslaboratoriet A normal APTT does not exclude mild, but clinically significant, coagulation factor deficiency (eg, as in mild haemophilia, von Willebrand disease) as many reagents give a prolonged APTT only at coagulation factor levels of 30% or below, presumably. An isolated prolongation of the APTT (PT normal) suggests deficiency of factor VIII, IX, XI or XII The aPTT is the most commonly used test to monitor heparin therapy. The therapeutic goal for a patient being anticoagulated with heparin, is an aPTT approximately 1.5 to 2.5 times the mean normal value The aPTT is not something you can change through lifestyle changes (unless perhaps you have a vitamin K induced factor deficiency). It is a reflection of the integrity of your clotting system. If your aPTT is prolonged due to acquired factor deficiencies, then addressing the underlying condition may bring the results to near normal levels

Bakgrund Effekten av AVK-behandling, mäts som koagulationstid i sekunder med hjälp av en reagens som ger en normal koagulationstid i teströret på 10-20 sekunder hos en obehandlad och 20-60 sekunder hos en warfarinbehandlad, välinställd patient. Tiderna är beroende på hur intensivt antikoagulerad patienten är och på vilket reagens och instrument som använts. Resultatet kan uttryckas. APTTP : The activated partial thromboplastin time (APTT) assay is used as a screening test to evaluate the overall integrity of the intrinsic/common coagulation pathway and to monitor patients on heparin therapy. This test reflects the activities of most of the coagulation factors in the intrinsic and common procoagulant pathway, but not the extrinsic procoagulant pathway, which includes. However, the APTT can be normal with mild deficiencies of these clotting factors. In general the deficient factor has to be less than 20-40% of normal before the APTT is prolonged [but see comments regarding APTT incubation times.] Contact factor deficiency e.g. pre-kallikrein deficiency, HMWK deficienc Chris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. He is also the Innovation Lead for the Australian Centre for Health Innovation at Alfred Health and Clinical Adjunct Associate Professor at Monash University.. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme

P- APT-tid - Unilab

The aPTT is considered a more sensitive version of the PTT and is used to monitor the patient's response to heparin therapy. The reference range of the aPTT is 30-40 seconds. [ 1 , 2 , 3 A normal aPTT with an abnormal PT means that the defect lies within the extrinsic pathway and suggests a possible factor VII deficiency. [1, 2, 6, 8] Normal hemostasis The APTT mixing study, which uses equal volumes of patient and normal pool plasma, may be performed on specimens with a prolonged APTT to assist in differentiating coagulation factor deficiencies from coagulation inhibitors of all types.(1-4) Correction of the APTT mix to within the normal reference range usually indicates a coagulation factor deficiency (normal plasma in the mixture ensures. The APTT and PT will detect 95% of coagulation abnormalities. When APTT is performed in conjunction with a prothrombin time (PT), a further clarification of coagulation defects is possible. For example, a normal PT and abnormal APTT means that the defect lies in the first stage of the clotting mechanism. Causes of prolonged APTT. Hemophili

A normal range is around 21 to 35 seconds. But test results will vary depending on equipment and methods used. So standard normal results will differ in each lab. If your aPTT takes longer than normal, it may mean several things. Often other tests are done at the same time as the aPTT to better find out which factors are involved Heparin anticoagulant therapy (the target aPTT is usually 1.5 to 2.5 times longer than that of a 'normal' control sample (referred to as the 'aPTT ratio'). Warfarin anticoagulation therapy. The aPTT is relatively insensitive to warfarin and not used to monitor therapy, but it may be affected by it partial thromboplastin time: Definition The partial thromboplastin time (PTT) test is a blood test that is done to investigate bleeding disorders and to monitor patients taking an anticlotting drug (heparin). Purpose Diagnosis Blood clotting (coagulation) depends on the action of substances in the blood called clotting factors. Measuring the.

Normal results are based on the way each laboratory measures the clotting factors. Healthy individuals may have mild to moderate clotting deficiencies on one more more factors and still have results that are interpreted as being normal. When there are prolonged APTT test results, then this is typically the result of an inherited factor deficiency Medicinsk bakgrund. APT-tid är ett screeningtest för aktiviteten av koagulationsfaktorerna i det s.k. intrinsic systemet; faktor XII, pre-kallikrein, kininogen, faktorerna XI, IX, VIII, protrombin, fibrinogen och även för faktorerna V och X. Observera att normal APT-tid inte med säkerhet utesluter en mild hemofili

Blödningstillstånd Läkemedelsboke

APTT-LA, Malmö Gäller för Klinisk kemi MA Utarbetad av Dokumentförvaltare Dokument id C-3137 Original lagras elektroniskt! Användaren ansvarar för att gällande revision används. APTT-LA (MAS-kod 02442), Malm In this video i'm going to show you how to do the #APTT test in #Hematology. The #principle, #procedure , #normal #range , purpose of the #test, precautions. The normal range of the APTT is 30 to 40 seconds. If the value exceeds 70 seconds, it indicates bleeding disorders. The reference value of APTT varies among laboratories due to the chemicals they use to perform the test INR and APTT are two types of test conducted to measure the coagulation of blood in the patient. INR stands for International Normalized Ratio. APTT, on the other hand, stands for Activated Partial Thromboplastin Time

Partial thromboplastin time - Wikipedi

APTT test results explained. APTT is the time in seconds for a specific clotting process to occur, in the laboratory test. This result is always compared to a control sample of normal blood. If the test sample takes longer than the control sample, it indicates decreased clotting function in the intrisic pathway The normal plasma supplies the deficient factor at a concentration high enough to allow normal clotting. In the absence of inhibitors, a sample with at least 50% of all factors will produce a normal clotting time for both the PT and aPTT tests aPTT-XL (Ellagic Acid Activator) (Product No. 10-0402): Superior factor sensitivity and responsiveness; Increased sensitivity to heparin and lupus-like inhibitors; KONTACT™ (Particulate Activator) (Product No. 01-0402): Higher sensitivity to Factor VIII; Average Normal Values: 26 - 33 Second The reference range of the aPTT is 30-40 seconds. [ 1, 2, 3] The reference range of the PTT is 60-70 seconds. In patients receiving anticoagulant therapy, the reference range is 1.5-2.5 times the.. Objective: To compare and contrast the activated partial thromboplastin time (aPTT) and the activated clotting time (ACT) for the therapeutic monitoring of heparin therapy. Data sources: Relevant articles were identified through an English-language MEDLINE search from 1966 to 1995. Additional sources were identified from the reference lists of these articles

Methods: A prospective study of consecutive patients with isolated prolonged APTT presenting to our hospital between February 2002 and January 2004 was performed. All patients had normal prothrombin time and thrombin time. For all patients, an initial 50:50 correction with plasma was done and a standard panel of tests was performed The APTT Ratio is used to monitor the anticoagulant unfractionated heparin. Principle of Assay. Please see Activated Partial Thromboplastin Time (APTT) Heparin Ratio Calculation. To calculate the Heparin ratio the APTT is divided by the MNAPTT. At each APTT LOT change normal plasmas are run as a comparison between the outgoing and incoming. In cases in which there is an isolated prolongation of the PT and the remainder of the screening tests (APTT, TT and Fibrinogen) are normal - the next most logical test is a Factor VII assay. Factor VII deficiency is rare and it is more common to find a prolonged PT in combination with other abnormalities of the screen e.g. a prolonged APTT Prover före: Hb, TPK, PK-INR, APTT, kreatinin, leverstatus I. Dalteparin . Dosering: Fulldos = 200 E/kg/dygn. Normalt givet som en injektion/dygn också vid lungemboli. Vid utbredd DVT eller stor lungemboli kan dosen 125 E/kg x 2 användas första dygnen. Förfyllda sprutor: 2 500, 5 000, 7 500, 10 000, 12 500, 15 000, 18 000 E . II

How is aPTT ratio calculated? - TreeHozz

Normal pooled plasma = NPP should be prepared from a minimum of 20 normal individuals (equal ratio of male to female), platelet poor (< 10 x 10 9 /L), tested negative for LA and have coagulation factor activities > 80%. Correction using Normal Plasma. Factor Deficiency : PT or APTT of the mixture returns to within a few seconds of normal Different labs have slightly different ranges for normal clotting time. But generally, clotting time is fine if it's within 25 to 35 seconds. If you're getting the test to monitor heparin, your normal will be higher -- usually between 60 and 100 seconds. If your results are above the normal range, your blood clots more slowly

The prothrombin time (PT) and activated partial thromboplastin time (APTT) are among the most commonly ordered coagulation tests. In 2005, more than 140,000 PT and more than 95,000 APTT tests were performed at Mayo Clinic. The most common indications for ordering these tests include anticoagulant monitoring, initial evaluation of hemorrhage, and, although not generally indicated, routine. The partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT or APTT) is a blood test that characterizes coagulation of the blood.A historical name for this measure is the kaolin-cephalin clotting time (KCCT), reflecting kaolin and cephalin as materials historically used in the test. Apart from detecting abnormalities in blood clotting, partial thromboplastin time is.

The partial thromboplastin time (PTT) and activated partial thromboplastin time (APTT) may be normal in people who have inherited bleeding disorders but have only mild symptoms. The APTT is used to check treatment of people who are using heparin or other blood-thinning medicine to prevent blood clots Normal test results may vary based on gender, age, health condition or history of the individual. The partial thromboplastin time is measured in seconds. If the aPTT time is greater than the normal reference range the individual may be suffering from diseases affecting blood and blood clotting like vitamin K deficiency, deficiency of blood clotting factors, cancers associated with blood and.

The aPTT may not be extended in individual factor deficiencies unless the levels drop below 15% to 45% depending on the factor. 6 Less significant individual factor deficiencies in combination (multiple factor deficiency) can extend the aPTT. 6 The aPTT is more sensitive to intrinsic pathway factor deficiencies than common pathway factor deficiencies. 6 Factor VIII elevations, as can occur due. An APTT below the reference range can be due to: elevated FVIII, FIX or fibrinogen activated sample Unexpectedly elevated APTTs additionally receive a mixing test, which is an APTT performed on a mixture of equal volumes of patient and normal plasma Partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem or if your blood does not clot properly

Partial Thromboplastin Time (PTT, aPTT) Lab Tests Onlin

A partial thromboplastin time (PTT) test measures the time it takes for a blood clot to form in a blood sample. It helps find out if you have a problem with your coagulation factors, proteins that work together to form blood clots. Learn more The second step in evaluating an unexpected prolonged aPTT and/or PT result should be to repeat the aPTT or PT assay, taking care to eliminate potential sources of preanalytical artifact. If the screening coagulation test continues to show prolonged times, the third step is to perform a mixing study on a 50:50 mixture of patient plasma and normal pooled plasma However, a repeat APTT is prolonged and a mixing study with normal plasma corrects the APTT. Further testing demonstrates normal factors IX and XI, but his level of factor VIII is only 10% of the reference range, confirming a diagnosis of hemophilia A. You advise Mr. K to get vaccinated against hepatitis A and B The aPTT is a blood test used to assess how fast the blood clots. aPTT stands from activated thromboplastin time. It assesses the intrinsic and common pathwa.. Different APTT reagents can then be used to test the samples and the data for each sample can be plotted again the upper reference limit of the APTT for each reagent [1]. The ratio of clotting time of each LA-positive sample (of varying strengths) to the mean normal APTT derived from normal plasma samples is calculated

Causes leading to lengthening of activated partial thromboplastin time (APTT) Violation of the indices of activated partial thromboplastin time (APTT) in normal prothrombin and thrombin time is observed only with the deficiency or inhibition of factors VIII, IX, XI, XII, as well as prekallikrein and high-molecular kininogen The classic laboratory findings in APLS patients are prolonged aPTT, normal PT, and no correction of the aPTT 1:1 mixing study. Adding excess phospholipid to the aPTT assay, however, reduces the clotting time. This is the basis for the so-called LA assay. One version of the LA assay is the dilute Russell's viper venom time (dRVVT)

ASAT - nivån är under normala omständigheter låg. Nivån av ASAT i blodet är under normala omständigheter låg. När kroppsvävnad eller ett organ som hjärta eller lever är sjuka eller skadade släpps ytterligare ASAT ut i blodomloppet. Mängden ASAT i blodet är direkt relaterad till omfattningen av vävnadsskada Normal PTT test results. PTT test results are measured in seconds. Normal results are typically 25 to 35 seconds. This means that it took your blood sample 25 to 35 seconds to clot after adding the chemicals. The exact standards for normal results may vary depending on your doctor and lab, so ask your doctor if you have any concerns Patients with von Willebrand's disease may have either normal or prolonged aPTTs, and patients with alpha 2-plasmin inhibitor deficiency have a normal aPTT. Both the PT and aPTT will be prolonged in patients with deficiencies of factors X, V, prothrombin, and fibrinogen, and in patients with DIC or severe liver disease ( Lusher 2003; Goodnight and Hathaway 2001 )

Coagulation assays eClinpat

To determine your test results, your PTT is compared to a normal control value. This value varies by laboratory, but generally, a normal range is 60 to 70 seconds for a PTT and 30 to 40 seconds for an aPTT. Keep in mind that your health and other factors must also be considered. Review your test results with your physician New Coagulation Normal Ranges, Heparin Protocol for APTT, and Critical Values Premier Pulse January 2019 Jan 1, 2019 The Miami Valley Hospital laboratory system - Miami Valley Hospital, Miami Valley Hospital South, Miami Valley Hospital North, Jamestown Emergency Center, and Austin Emergency Center - will be going live with new coagulation instrumentation January 30, 2019 The normal APTT (Activated Partial Thromboplastin Time) value is 35 seconds. Difference between PTT and APTT. Definition; PTT. PTT is the best single screening test conducted to assess coagulation disorders. APTT. It is same as PTT, but measures effectiveness of Heparin (more specific than Partial Thromboplastin Time)

Hemofili och annan blödarsjuka analyseras genom PK-INR

APTT, Tromboplastintid, partiell, aktiverad, P-APT-tid

Comparison of two APTT methods of monitoring heparin therapy. APTT ratio and heparin response of pooled normal plasma. Zanke B(1), Shojania AM. Author information: (1)Department of Hematology, St. Boniface General Hospital, Winnipeg, Canada. The sensitivity of the reagents for activated partial thromboplastin time (APTT) test varies greatly Disorder Deficient factor PT* APTT* Prevalence Mode of inheritance Hemophilia A Factor VIII Normal Prolonged 1:5000† X-linked recessive Hemophilia B Factor IX Normal Prolonged 1:30,000† X-linked recessive Hemophilia C Factor XI Normal Prolonged Up to 4%‡ Autosoma raised APTT due to secondary haemophilia The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions 1 The Patient is Bleeding & the PT/aPTT are Normal Dorothy Adcock, MD Title: The patient is bleeding but the APTT and PT are normal As Dr. Worfolk mentioned, the topic of the discussion this morning, the patient is bleeding, but the aPTT and PT are normal

aPTT: [ tīm ] a measure of duration. See under adjectives for specific times, such as bleeding time . activated partial thromboplastin time (APTT, aPTT) the period required for clot formation in recalcified blood plasma after contact activation and the addition of platelet substitutes such as brain cephalins or similar phospholipids ; used to. This review will highlight the similarities and differences between the PT/INR vs. aPTT test for exams! The PT/INR and aPTT are helpful tests for assessing the coagulation process. As the nurse you want to know their normal ranges, what each test assesses, how their used to monitor anticoagulation therapy, and the nurse's role

The normal aPTT value is 35 seconds. What is PTT. PTT (partial thromboplastin time) refers to a test used to measure the time taken for the blood clotting. This is used for the diagnosis of bleeding problems. During PTT, the integrity of the intrinsic system is measured by means of factors VIII, IX, XI, and XII Normal range for an aPTT: 30-40 seconds (approximate) results higher than this means the patient has a prolonged time forming a clot. aPTT vs PTT? It measures the same thing, but an activator agent is added to the aPTT to speed up the clotting time, which makes the results have a smaller range compared to the PTT

Partial Thromboplastin Time, Activated: Reference Range

II. Check a thrombin time and reptilase time (if TT is prolonged and reptiplase time normal, heparin is likely present) III. Perform an inhibitor screen (mixing study): pt plasma is mixed with normal plasma and aPTT is rechecked after 1-2 hrs Sample type: Whole Blood Test name: APTT a.k.a. Activated Partial Thromboplastin Time Special precautions & notes: Must be assayed same day Reference range: 21 - 33 sec (not on anticoagulants), Therapeutic ratio (1.5 - 2.5) Container: Citrate (Blue top) Ideal volume (mL): 2.7 mL Discipline: Haematolog The aPTT test uses blood which is decalcified to prevent clotting before the test begins. The plasma is separated by centrifugation. (Ionized) Calcium and activating substances are added to the plasma to start the intrinsic pathway of the coagulation cascade The APTT will generally be prolonged when a clotting factor level is less than 30-40%. Since the normal range for most clotting factors is 50-150% (and 70-130% for factor XI), a normal APTT does not rule out the possibility of a mild factor deficiency. The test is performed by adding PTT reagent to plasma and measuring the time for clot formation Repeating the test using a mix of test plasma and normal plasma can help differentiate these possibilities: PT returns to normal limits when normal plasma is added to factor-deficient plasma, but no change is seen when this is added to plasma containing inibitors 3. PT is more sensitive than APTT for factor deficiencies

Tests for hemostasis generally fall under the categories of primary and secondary hemostasis, fibrinolysis and testing for inhibitors. We have also provided a diagnostic algorithm for test interpretation and a table summaries of thrombocytopenia mechanisms and interpretation of coagulation screening assays. Further information is available on all coagulation tests offered by the Animal Health. The normal prothrombin time (PT) is approximately 9 to 12 seconds and the normal activated partial thromboplastin time (APTT) is approximately 26 to 36 seconds. The test result can either be normal or prolonged (sometime referred to as high). Results. Normal PT

Blodanalys av koagulering via P-APT-tid Medisera Healt

The normal range for coagulation assay not yet been established in India even though we are second most populated country in the world. Recently in this study, we tried to establish normal ranges of PT, APTT, TT, and fibrinogen in the Indian population aPTT from the PTT. The aPTT assay resolution is achieved through the use of a platelet factor 3 substitute and a kaolin activator, and does not require an incubation step. Principle of Operation The coagulation analyzer utilizes a mechanical end point clotting mechanism in which clot formation occurs within the disposable aPTT cartridge A partial thromboplastin time (PTT) test is used to evaluate blood's ability to clot. It may be done as part of an evaluation for a bleeding disorder or to monitor the effects of blood-thinning medicine APTT run on it as a reportable result and to confirm its normal status. 2. Mix an aliquot of Patient sample with an equal amount of Normal Plasma (200µL of each works well to allow replicate tests if necessary) 3. Perform the PT and/or APTT test in the same manor as previous. Report: 1 Normalt INR, utan warfarinbehandling, är 1. INR-värdet stiger sedan, beroende på hur stor inverkan medicinen har på blodets koaguleringsförmåga. Vid ett INR-värde på 10 koagulerar blodet.

Rcpa - Aptt

The partial thromboplastin time (PTT; also known as activated partial thromboplastin time (aPTT)) is a screening test that helps evaluate a person's ability to appropriately form blood clots. It measures the number of seconds it takes for a clot to form in a sample of blood after substances (reagents) are added This APTT screening test is also used to ensure whether the right dose of heparin is being used. The given below is the activated partial thromboplastin time normal range chart which shows you the APTT normal range for all ages

The APTT and PT/INR can fall in the normal or near‐normal range in a patient fully anticoagulated on one of the DOACS and this is most likely to occur with apixaban therapy. Clinicians must acknowledge that the APTT and PT can no longer be used as a general gauge of a patient's level of anticoagulation and hence bleeding risk INR and APTT are both important tests for determining your blood coagulation. They serve as precautionary measures whether an anticoagulant drug is effective on you or not. They are also important in pre-surgical checklists since, after the operation, a normal blood clotting is needed for your wound to eventually close up and stop bleeding

Normal range for PT is typically between 11-14 seconds. Normal range for APTT is typically between 25-35 seconds. This information was gathered from the University of California, San Francisco. The APTT Ratio is used to monitor patients on full dose Heparin. Low molecular weight Heparin (LMWH) has little effect on the APTT result, and monitoring is usually not necessary. Samples MUST be filled appropriately (there may be a frosted fill line) aptt FREE subscriptions for doctors and students... click here You have 3 open access pages. The activated partial thromboplastin time is equivalent to the Kaolin cephalin clotting time, and is a measure of the activity of the intrinsic pathway of coagulation (VIII, IX, XI, XII)

COVID-19 has had an enormous impact on our lives and as the world attempts to return to a new normal it is essential that we protect ourselves and our loved ones. With APT™ T3X, you can safely get back to work, see your kids off to school, and visit friends and family with the confidence that you are protected APTT; PTT; Activated partial thromboplastin time. How the test is performed. The health care provider uses a needle to take blood from one of your veins. The blood collects into an air-tight container. You may be given a bandage to stop any bleeding. If you are taking a medicine called heparin, you will be watched for signs of bleeding

Use of a Fixed Activated Partial Thromboplastin Time RatioHematology-Oncology Review SessionPPT - ASCITES PowerPoint Presentation - ID:4730573Anticoagulant, Antiagregant Therapy - презентация онлайнHaemophilia - Approach | BMJ Best PracticeAnticoagulant, Antiagregant Therapy - online presentationSolitary nodule of angiolymphoid hyperplasia withCommon anticoagulants and antiplatlets in dentristry
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